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2015 ; 39
(ä): 91-6
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Survivin - The inconvenient IAP
#MMPMID25591986
Altieri DC
Semin Cell Dev Biol
2015[Mar]; 39
(ä): 91-6
PMID25591986
show ga
Although technically a member of the Inhibitor of Apoptosis (IAP) gene family,
survivin has consistently defied assumptions, refuted predictions and challenged
paradigms. Despite its more than 5500 citations currently in Medline, the biology
of survivin has remained fascinatingly complex, its exploitation in human
disease, most notably cancer, tantalizing, and its regulation of cellular
homeostasis unexpectedly far-reaching. An inconvenient outsider that resists
schemes and dogmas, survivin continues to hold great promise to unlock
fundamental circuitries of cellular functions in health and disease.
|*Signal Transduction
[MESH]
|Animals
[MESH]
|Cell Division
[MESH]
|Cell Survival
[MESH]
|Humans
[MESH]
|Inhibitor of Apoptosis Proteins/chemistry/*genetics/*metabolism
[MESH]