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10.1002/pst.1756

http://scihub22266oqcxt.onion/10.1002/pst.1756
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C5468795!5468795 !27307025
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suck abstract from ncbi


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pmid27307025
      Pharm+Stat 2016 ; 15 (5 ): 405-11
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  • Survival trial design and monitoring using historical controls #MMPMID27307025
  • Wu J ; Xiong X
  • Pharm Stat 2016[Sep]; 15 (5 ): 405-11 PMID27307025 show ga
  • In this paper, we propose a multistage group sequential procedure to design survival trials using historical controls. The formula for the number of events required for historical control trial designs is derived. Furthermore, a transformed information time is proposed for trial monitoring. An example is given to illustrate the application of the proposed methods to survival trial designs using historical controls. Copyright © 2016 John Wiley & Sons, Ltd.
  • |Double-Blind Method [MESH]
  • |Humans [MESH]
  • |Liver Cirrhosis, Biliary/*drug therapy/*mortality [MESH]
  • |Models, Statistical [MESH]
  • |Penicillamine/*therapeutic use [MESH]
  • |Randomized Controlled Trials as Topic/methods/*statistics & numerical data [MESH]
  • |Research Design/*statistics & numerical data [MESH]
  • |Sample Size [MESH]


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