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Survival of Children With Hypoplastic Left Heart Syndrome
#MMPMID26391936
Siffel C
; Riehle-Colarusso T
; Oster ME
; Correa A
Pediatrics
2015[Oct]; 136
(4
): e864-70
PMID26391936
show ga
OBJECTIVE: To examine the survival of infants with hypoplastic left heart
syndrome (HLHS) and potential influence of demographic and clinical
characteristics on survival using population-based data. METHODS: Infants with
nonsyndromic HLHS (n = 212) born between 1979 and 2005 were identified through
the Metropolitan Atlanta Congenital Defects Program. Vital status was ascertained
through 2009 based on linkage with vital records. We estimated Kaplan-Meier
survival probabilities stratified by select demographic and clinical
characteristics. RESULTS: The overall survival probability to 2009 was 24% and
significantly improved over time: from 0% in 1979-1984 to 42% in 1999-2005.
Survival probability was 66% during the first week, 27% during the first year of
life, and 24% during the first 10 years. Survival of very low and low birth
weight or preterm infants and those born in high-poverty neighborhoods was
significantly poorer. For children with information on surgical intervention (n =
88), the overall survival was 52%, and preterm infants had significantly poorer
survival (31%) compared with term infants (56%). For children who survived to 1
year of age, long-term survival was ?90%. CONCLUSIONS: Survival to adolescence of
children with nonsyndromic HLHS born in metropolitan Atlanta has significantly
improved in recent years, with those born full term, with normal birth weight, or
in a low-poverty neighborhood having a higher survival probability. Survival
beyond infancy to adolescence is high. A better understanding of the growing
population of survivors with HLHS is needed to inform resource planning.
|Child
[MESH]
|Female
[MESH]
|Follow-Up Studies
[MESH]
|Georgia
[MESH]
|Humans
[MESH]
|Hypoplastic Left Heart Syndrome/*mortality/surgery
[MESH]
free
free
free
