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2016 ; 11
(1
): 47
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Surgical and molecular pathology of pancreatic neoplasms
#MMPMID27267993
Diagn Pathol
2016[Jun]; 11
(1
): 47
PMID27267993
show ga
BACKGROUND: Histologic characteristics have proven to be very useful for
classifying different types of tumors of the pancreas. As a result, the major
tumor types in the pancreas have long been classified based on their microscopic
appearance. MAIN BODY: Recent advances in whole exome sequencing, gene expression
profiling, and knowledge of tumorigenic pathways have deepened our understanding
of the underlying biology of pancreatic neoplasia. These advances have not only
confirmed the traditional histologic classification system, but also opened new
doors to early diagnosis and targeted treatment. CONCLUSION: This review
discusses the histopathology, genetic and epigenetic alterations and potential
treatment targets of the five major malignant pancreatic tumors - pancreatic
ductal adenocarcinoma, pancreatic neuroendocrine tumor, solid-pseudopapillary
neoplasm, acinar cell carcinoma and pancreatoblastoma.