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10.1158/0008-5472.CAN-16-1536 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-16-1536 C5380551!5380551 !28330928     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28330928 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Cancer+Res 2017 ; 77 (7 ): 1548-1552 Nephropedia Template TP {{tp|p=28330928 |t=2017. Surgery for Cancer: A Trigger for Metastases |pdf=|usr=}}{{28330928 }} gab.com Text Surgery for Cancer: A Trigger for Metastases JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28330928 #FOAvip Surgery is a crucial intervention and provides a chance of cure for patients with cancer. The perioperative period is characterized by an increased risk for accelerated growth of micrometastatic disease and increased formation of new metastatic foci. The true impact for cancer patients remains unclear. This review summarizes the often fragmentary clinical and experimental evidence supporting the role of surgery and inflammation as potential triggers for disease recurrence. Surgery induces increased shedding of cancer cells into the circulation, suppresses antitumor immunity allowing circulating cells to survive, upregulates adhesion molecules in target organs, recruits immune cells capable of entrapping tumor cells, and induces changes in the target tissue and in the cancer cells themselves to enhance migration and invasion to establish at the target site. Surgical trauma induces local and systemic inflammatory responses that can also contribute to the accelerated growth of residual and micrometastatic disease. Furthermore, we address the role of perioperative factors, including anesthesia, transfusions, hypothermia, and postoperative complications, as probable deleterious factors contributing to early recurrence. Through the admittedly limited understanding of these processes, we will attempt to provide suggestions for potential new therapeutic approaches to target the protumorigenic perioperative window and ultimately improve long-term oncological outcomes. Cancer Res; 77(7); 1548-52. ©2017 AACR. Twit Text FOAVip Surgery for Cancer: A Trigger for Metastases ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28330928 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28330928 #FOAvip English Wikipedia <ref>{{Cite pmid|28330928 }}</ref> Surgery for Cancer: A Trigger for Metastases #MMPMID28330928 Tohme S ; Simmons RL ; Tsung A Cancer Res 2017[Apr]; 77 (7 ): 1548-1552 PMID28330928 show ga Surgery is a crucial intervention and provides a chance of cure for patients with cancer. The perioperative period is characterized by an increased risk for accelerated growth of micrometastatic disease and increased formation of new metastatic foci. The true impact for cancer patients remains unclear. This review summarizes the often fragmentary clinical and experimental evidence supporting the role of surgery and inflammation as potential triggers for disease recurrence. Surgery induces increased shedding of cancer cells into the circulation, suppresses antitumor immunity allowing circulating cells to survive, upregulates adhesion molecules in target organs, recruits immune cells capable of entrapping tumor cells, and induces changes in the target tissue and in the cancer cells themselves to enhance migration and invasion to establish at the target site. Surgical trauma induces local and systemic inflammatory responses that can also contribute to the accelerated growth of residual and micrometastatic disease. Furthermore, we address the role of perioperative factors, including anesthesia, transfusions, hypothermia, and postoperative complications, as probable deleterious factors contributing to early recurrence. Through the admittedly limited understanding of these processes, we will attempt to provide suggestions for potential new therapeutic approaches to target the protumorigenic perioperative window and ultimately improve long-term oncological outcomes. Cancer Res; 77(7); 1548-52. ©2017 AACR. |*Neoplasm Metastasis [MESH] |Cell Movement [MESH] |Humans [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Micrometastasis [MESH] |Neoplasm Recurrence, Local/etiology [MESH] |Neoplasm, Residual [MESH] |Neoplasms/*surgery [MESH]Surgery for Cancer: A Trigger for Metastases (epmc).pdf DeepDyve Pubget Overpricing