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2016 ; 129
(2
): 206-14
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Surface Modification of Intraocular Lenses
#MMPMID26830993
Huang Q
; Cheng GP
; Chiu K
; Wang GQ
Chin Med J (Engl)
2016[Jan]; 129
(2
): 206-14
PMID26830993
show ga
OBJECTIVE: This paper aimed to review the current literature on the surface
modification of intraocular lenses (IOLs). DATA SOURCES: All articles about
surface modification of IOLs published up to 2015 were identified through a
literature search on both PubMed and ScienceDirect. STUDY SELECTION: The articles
on the surface modification of IOLs were included, but those on design
modification and surface coating were excluded. RESULTS: Technology of surface
modification included plasma, ion beam, layer-by-layer self-assembly, ultraviolet
radiation, and ozone. The main molecules introduced into IOLs surface were poly
(ethylene glycol), polyhedral oligomeric silsesquioxane, 2-methacryloyloxyethyl
phosphorylcholine, TiO 2 , heparin, F-heparin, titanium, titanium nitride, vinyl
pyrrolidone, and inhibitors of cytokines. The surface modification either
resulted in a more hydrophobic lens, a more hydrophilic lens, or a lens with a
hydrophilic anterior and hydrophobic posterior surface. Advances in research
regarding surface modification of IOLs had led to a better biocompatibility in
both in vitro and animal experiments. CONCLUSION: The surface modification is an
efficient, convenient, economic and promising method to improve the
biocompatibility of IOLs.
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