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10.1038/s41467-018-04247-z

http://scihub22266oqcxt.onion/10.1038/s41467-018-04247-z
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suck abstract from ncbi


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pmid29739936
      Nat+Commun 2018 ; 9 (1 ): 1815
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  • Supramolecular Kandinsky circles with high antibacterial activity #MMPMID29739936
  • Wang H ; Qian X ; Wang K ; Su M ; Haoyang WW ; Jiang X ; Brzozowski R ; Wang M ; Gao X ; Li Y ; Xu B ; Eswara P ; Hao XQ ; Gong W ; Hou JL ; Cai J ; Li X
  • Nat Commun 2018[May]; 9 (1 ): 1815 PMID29739936 show ga
  • Nested concentric structures widely exist in nature and designed systems with circles, polygons, polyhedra, and spheres sharing the same center or axis. It still remains challenging to construct discrete nested architecture at (supra)molecular level. Herein, three generations (G2-G4) of giant nested supramolecules, or Kandinsky circles, have been designed and assembled with molecular weight 17,964, 27,713 and 38,352?Da, respectively. In the ligand preparation, consecutive condensation between precursors with primary amines and pyrylium salts is applied to modularize the synthesis. These discrete nested supramolecules are prone to assemble into tubular nanostructures through hierarchical self-assembly. Furthermore, nested supramolecules display high antimicrobial activity against Gram-positive pathogen methicillin-resistant Staphylococcus aureus (MRSA), and negligible toxicity to eukaryotic cells, while the corresponding ligands do not show potent antimicrobial activity.
  • |Anti-Bacterial Agents/*chemistry/pharmacology/therapeutic use [MESH]
  • |Drug Resistance, Bacterial [MESH]
  • |Hydrophobic and Hydrophilic Interactions [MESH]
  • |Ligands [MESH]
  • |Macromolecular Substances/*chemistry/pharmacology/therapeutic use [MESH]
  • |Methicillin-Resistant Staphylococcus aureus/*drug effects/isolation & purification [MESH]
  • |Microbial Sensitivity Tests [MESH]
  • |Microscopy, Atomic Force [MESH]
  • |Microscopy, Electron, Transmission [MESH]
  • |Molecular Weight [MESH]
  • |Nanostructures [MESH]
  • |Proton Magnetic Resonance Spectroscopy [MESH]


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