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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Nat+Commun
2018 ; 9
(1
): 1815
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Supramolecular Kandinsky circles with high antibacterial activity
#MMPMID29739936
Wang H
; Qian X
; Wang K
; Su M
; Haoyang WW
; Jiang X
; Brzozowski R
; Wang M
; Gao X
; Li Y
; Xu B
; Eswara P
; Hao XQ
; Gong W
; Hou JL
; Cai J
; Li X
Nat Commun
2018[May]; 9
(1
): 1815
PMID29739936
show ga
Nested concentric structures widely exist in nature and designed systems with
circles, polygons, polyhedra, and spheres sharing the same center or axis. It
still remains challenging to construct discrete nested architecture at
(supra)molecular level. Herein, three generations (G2-G4) of giant nested
supramolecules, or Kandinsky circles, have been designed and assembled with
molecular weight 17,964, 27,713 and 38,352?Da, respectively. In the ligand
preparation, consecutive condensation between precursors with primary amines and
pyrylium salts is applied to modularize the synthesis. These discrete nested
supramolecules are prone to assemble into tubular nanostructures through
hierarchical self-assembly. Furthermore, nested supramolecules display high
antimicrobial activity against Gram-positive pathogen methicillin-resistant
Staphylococcus aureus (MRSA), and negligible toxicity to eukaryotic cells, while
the corresponding ligands do not show potent antimicrobial activity.
|Anti-Bacterial Agents/*chemistry/pharmacology/therapeutic use
[MESH]
|Drug Resistance, Bacterial
[MESH]
|Hydrophobic and Hydrophilic Interactions
[MESH]
|Ligands
[MESH]
|Macromolecular Substances/*chemistry/pharmacology/therapeutic use
[MESH]