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10.1038/nature09589 http://scihub22266oqcxt.onion/10.1038/nature09589 C5415086!5415086 !21068722     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21068722 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\21068722 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nature 2010 ; 468 (7327 ): 1119-23 Nephropedia Template TP {{tp|p=21068722 |t=2010. Suppression of inflammation by a synthetic histone mimic |pdf=|usr=}}{{21068722 }} gab.com Text Suppression of inflammation by a synthetic histone mimic JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=21068722 #FOAvip Interaction of pathogens with cells of the immune system results in activation of inflammatory gene expression. This response, although vital for immune defence, is frequently deleterious to the host due to the exaggerated production of inflammatory proteins. The scope of inflammatory responses reflects the activation state of signalling proteins upstream of inflammatory genes as well as signal-induced assembly of nuclear chromatin complexes that support mRNA expression. Recognition of post-translationally modified histones by nuclear proteins that initiate mRNA transcription and support mRNA elongation is a critical step in the regulation of gene expression. Here we present a novel pharmacological approach that targets inflammatory gene expression by interfering with the recognition of acetylated histones by the bromodomain and extra terminal domain (BET) family of proteins. We describe a synthetic compound (I-BET) that by 'mimicking' acetylated histones disrupts chromatin complexes responsible for the expression of key inflammatory genes in activated macrophages, and confers protection against lipopolysaccharide-induced endotoxic shock and bacteria-induced sepsis. Our findings suggest that synthetic compounds specifically targeting proteins that recognize post-translationally modified histones can serve as a new generation of immunomodulatory drugs. Twit Text FOAVip Suppression of inflammation by a synthetic histone mimic ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=21068722 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21068722 #FOAvip English Wikipedia <ref>{{Cite pmid|21068722 }}</ref> Suppression of inflammation by a synthetic histone mimic #MMPMID21068722 Nicodeme E ; Jeffrey KL ; Schaefer U ; Beinke S ; Dewell S ; Chung CW ; Chandwani R ; Marazzi I ; Wilson P ; Coste H ; White J ; Kirilovsky J ; Rice CM ; Lora JM ; Prinjha RK ; Lee K ; Tarakhovsky A Nature 2010[Dec]; 468 (7327 ): 1119-23 PMID21068722 show ga Interaction of pathogens with cells of the immune system results in activation of inflammatory gene expression. This response, although vital for immune defence, is frequently deleterious to the host due to the exaggerated production of inflammatory proteins. The scope of inflammatory responses reflects the activation state of signalling proteins upstream of inflammatory genes as well as signal-induced assembly of nuclear chromatin complexes that support mRNA expression. Recognition of post-translationally modified histones by nuclear proteins that initiate mRNA transcription and support mRNA elongation is a critical step in the regulation of gene expression. Here we present a novel pharmacological approach that targets inflammatory gene expression by interfering with the recognition of acetylated histones by the bromodomain and extra terminal domain (BET) family of proteins. We describe a synthetic compound (I-BET) that by 'mimicking' acetylated histones disrupts chromatin complexes responsible for the expression of key inflammatory genes in activated macrophages, and confers protection against lipopolysaccharide-induced endotoxic shock and bacteria-induced sepsis. Our findings suggest that synthetic compounds specifically targeting proteins that recognize post-translationally modified histones can serve as a new generation of immunomodulatory drugs. |*Inflammation/drug therapy/prevention & control [MESH] |Acetylation/drug effects [MESH] |Animals [MESH] |Anti-Inflammatory Agents/chemistry/*pharmacology/therapeutic use [MESH] |Benzodiazepines [MESH] |Cells, Cultured [MESH] |Epigenomics [MESH] |Gene Expression Regulation/*drug effects [MESH] |Genome-Wide Association Study [MESH] |Heterocyclic Compounds, 4 or More Rings/chemistry/*pharmacology/therapeutic use [MESH] |Histone Deacetylase Inhibitors/pharmacology [MESH] |Hydroxamic Acids/pharmacology [MESH] |Kaplan-Meier Estimate [MESH] |Lipopolysaccharides/pharmacology [MESH] |Macrophages/*drug effects [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Models, Molecular [MESH] |Protein Serine-Threonine Kinases/metabolism [MESH] |Protein Structure, Tertiary [MESH] |Salmonella Infections/drug therapy/immunology/physiopathology/prevention & control [MESH] |Salmonella typhimurium [MESH] |Sepsis/drug therapy/prevention & control [MESH]Suppression of inflammation by a synthetic histone mimic (epmc).pdf DeepDyve Pubget Overpricing