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10.15252/embj.201797469 http://scihub22266oqcxt.onion/10.15252/embj.201797469 C5502876!5502876 !28623241     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28623241 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28623241 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+J 2017 ; 36 (13 ): 1809-1810 Nephropedia Template TP {{tp|p=28623241 |t=2017. Suppressing mTORC1 on the lysosome |pdf=|usr=}}{{28623241 }} gab.com Text Suppressing mTORC1 on the lysosome JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=28623241 #FOAvip The mechanistic target of rapamycin, mTOR, is a protein kinase that integrates environmental and nutritional inputs into regulation of cell growth and metabolism. Key outputs of mTOR signalling occur from the lysosome membrane in the form of the multi?subunit mTOR complex 1 (mTORC1), which phosphorylates multiple targets. While class I phosphoinositide kinase (PI3K?I) is a well?known activator of mTORC1, a recent paper (Marat et al, 2017) shows that a class II PI3K with a different substrate specificity, PI3K?C2?, serves to inhibit mTORC1 on lysosomes under conditions of growth factor deprivation. Twit Text FOAVip Suppressing mTORC1 on the lysosome ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=28623241 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28623241 #FOAvip English Wikipedia <ref>{{Cite pmid|28623241 }}</ref> Suppressing mTORC1 on the lysosome #MMPMID28623241 Raiborg C ; Schink KO ; Stenmark H EMBO J 2017[Jul]; 36 (13 ): 1809-1810 PMID28623241 show ga The mechanistic target of rapamycin, mTOR, is a protein kinase that integrates environmental and nutritional inputs into regulation of cell growth and metabolism. Key outputs of mTOR signalling occur from the lysosome membrane in the form of the multi?subunit mTOR complex 1 (mTORC1), which phosphorylates multiple targets. While class I phosphoinositide kinase (PI3K?I) is a well?known activator of mTORC1, a recent paper (Marat et al, 2017) shows that a class II PI3K with a different substrate specificity, PI3K?C2?, serves to inhibit mTORC1 on lysosomes under conditions of growth factor deprivation. |*Lysosomes [MESH] |*Mechanistic Target of Rapamycin Complex 1 [MESH] |Multiprotein Complexes [MESH]Suppressing mTORC1 on the lysosome (epmc).pdf DeepDyve Pubget Overpricing