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2016 ; 11
(6
): e0156479
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Supporting Regularized Logistic Regression Privately and Efficiently
#MMPMID27271738
Li W
; Liu H
; Yang P
; Xie W
PLoS One
2016[]; 11
(6
): e0156479
PMID27271738
show ga
As one of the most popular statistical and machine learning models, logistic
regression with regularization has found wide adoption in biomedicine, social
sciences, information technology, and so on. These domains often involve data of
human subjects that are contingent upon strict privacy regulations. Concerns over
data privacy make it increasingly difficult to coordinate and conduct large-scale
collaborative studies, which typically rely on cross-institution data sharing and
joint analysis. Our work here focuses on safeguarding regularized logistic
regression, a widely-used statistical model while at the same time has not been
investigated from a data security and privacy perspective. We consider a common
use scenario of multi-institution collaborative studies, such as in the form of
research consortia or networks as widely seen in genetics, epidemiology, social
sciences, etc. To make our privacy-enhancing solution practical, we demonstrate a
non-conventional and computationally efficient method leveraging distributing
computing and strong cryptography to provide comprehensive protection over
individual-level and summary data. Extensive empirical evaluations on several
studies validate the privacy guarantee, efficiency and scalability of our
proposal. We also discuss the practical implications of our solution for
large-scale studies and applications from various disciplines, including genetic
and biomedical studies, smart grid, network analysis, etc.
|*Computer Security
[MESH]
|*Logistic Models
[MESH]
|*Machine Learning/standards
[MESH]
|*Privacy
[MESH]
|Computer Communication Networks/organization &
administration/standards/statistics & numerical data
[MESH]