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2017 ; 7
(1
): 9651
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Super-Resolved Nuclear Magnetic Resonance Spectroscopy
#MMPMID28851979
Mulleti S
; Singh A
; Brahmkhatri VP
; Chandra K
; Raza T
; Mukherjee SP
; Seelamantula CS
; Atreya HS
Sci Rep
2017[Aug]; 7
(1
): 9651
PMID28851979
show ga
We present a novel method that breaks the resolution barrier in nuclear magnetic
resonance (NMR) spectroscopy, allowing one to accurately estimate the chemical
shift values of highly overlapping or broadened peaks. This problem is routinely
encountered in NMR when peaks have large linewidths due to rapidly decaying
signals, hindering its application. We address this problem based on the notion
of finite-rate-of-innovation (FRI) sampling, which is based on the premise that
signals such as the NMR signal, can be accurately reconstructed using fewer
measurements than that required by existing approaches. The FRI approach leads to
super-resolution, beyond the limits of contemporary NMR techniques. Using this
method, we could measure for the first time small changes in chemical shifts
during the formation of a Gold nanorod-protein complex, facilitating the
quantification of the strength of such interactions. The method thus opens up new
possibilities for the application and acceleration of multidimensional NMR
spectroscopy across a wide range of systems.