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2013 ; 52
(22
): 3829-40
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Sum of the parts: mass spectrometry-based metabolomics
#MMPMID23442130
Milne SB
; Mathews TP
; Myers DS
; Ivanova PT
; Brown HA
Biochemistry
2013[Jun]; 52
(22
): 3829-40
PMID23442130
show ga
Metabolomics is a rapidly growing field of research used in the identification
and quantification of the small molecule metabolites within an organism, thereby
providing insights into cell metabolism and bioenergetics as well as processes
important in clinical medicine, such as disposition of pharmaceutical compounds.
It offers comprehensive information about thousands of low-molecular mass
compounds (<1500 Da) that represent a wide range of pathways and intermediary
metabolism. Because of its vast expansion in the past two decades, mass
spectrometry has become an indispensable tool in "omic" analyses. The use of
different ionization techniques such as the more traditional electrospray and
matrix-assisted laser desorption, as well as recently popular desorption
electrospray ionization, has allowed the analysis of a wide range of biomolecules
(e.g., peptides, proteins, lipids, and sugars), and their imaging and analysis in
the original sample environment in a workup free fashion. An overview of the
current state of the methodology is given, as well as examples of application.
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