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2017 ; 145
(6
): 738-745
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Sudden unexpected death in epilepsy
#MMPMID29067975
Duble SN
; Thomas SV
Indian J Med Res
2017[Jun]; 145
(6
): 738-745
PMID29067975
show ga
People with epilepsy have increased risk of premature death, and their life
expectancy may reduce by 2-10 yr. Population- and hospital-based studies have
shown that the excess mortality in epilepsy is not entirely explained by deaths
directly attributable to epilepsy such as accidents and drowning during a
seizure. It is also significantly contributed by deaths from other causes such as
cardiac deaths, deaths due to malignancies and other causes. It had recently been
recognized that sudden unexpected deaths in epilepsy (SUDEP) contributed to a
small yet important proportion of mortality in epilepsy. SUDEPs are deaths
(witnessed or unwitnessed) unrelated to trauma, drowning or status epilepticus
and not attributable to any specific medical conditions. Several factors related
to epilepsy and drug therapy have been found to be associated with higher risk of
SUDEP.