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2017 ; 12
(1
): 67
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Subventricular zones: new key targets for glioblastoma treatment
#MMPMID28424082
Khalifa J
; Tensaouti F
; Lusque A
; Plas B
; Lotterie JA
; Benouaich-Amiel A
; Uro-Coste E
; Lubrano V
; Cohen-Jonathan Moyal E
Radiat Oncol
2017[Apr]; 12
(1
): 67
PMID28424082
show ga
BACKGROUND: We aimed to identify subventricular zone (SVZ)-related prognostic
factors of survival and patterns of recurrence among patients with glioblastoma.
METHODS: Forty-three patients with primary diagnosed glioblastoma treated in our
Cancer Center between 2006 and 2010 were identified. All patients received
surgical resection, followed by temozolomide-based chemoradiation. Ipsilateral
(iSVZ), contralateral (cSVZ) and bilateral (bSVZ) SVZs were retrospectively
segmented and radiation dose-volume histograms were generated. Multivariate
analysis using the Cox proportional hazards model was assessed to examine the
relationship between prognostic factors and time to progression (TTP) or overall
survival (OS). RESULTS: Median age was 59 years (range: 25-85). Median follow-up,
OS and TTP were 22.7 months (range 7.5-69.7 months), 22.7 months (95% CI
14.5-26.2 months) and 6.4 months (95% CI 4.4-9.3 months), respectively. On
univariate analysis, initial contact to SVZ was a poor prognostic factor for OS
(18.7 vs 41.7 months, p?=?0.014) and TTP (4.6 vs 12.9 months, p?=?0.002).
Patients whose bSVZ volume receiving at least 20 Gy (V20Gy) was greater than 84%
had a significantly improved TTP (17.7 months vs 5.2 months, p?=?0.017). This
radiation dose coverage was compatible with an hippocampal sparing. On
multivariate analysis, initial contact to SVZ and V20 Gy to bSVZ lesser than 84%
remained poor prognostic factors for TTP (HR?=?3.07, p?=?0.012 and HR?=?2.67,
p?=?0.047, respectively). CONCLUSION: Our results suggest that contact to SVZ, as
well as insufficient bSVZ radiation dose coverage (V20Gy <84%), might be
independent poor prognostic factors for TTP. Therefore, targeting SVZ could be of
crucial interest for optimizing glioblastoma treatment.
|Adult
[MESH]
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
[MESH]
free
free
free
