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2017 ; 51
(1
): 43-46
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Subcutaneous basidiobolomycosis: A Case Report
#MMPMID28959073
Sackey A
; Ghartey N
; Gyasi R
Ghana Med J
2017[Mar]; 51
(1
): 43-46
PMID28959073
show ga
Basidiobolomycosis is an uncommon chronic deep fungal infection in which
gradually enlarging granulomas form, usually in the subcutaneous fat tissues of
the limbs, chest or trunk of immunocompetent hosts, primarily children and young
adults. It is caused by the fungus Basidiobolus ranarum. Definitive diagnosis is
by microscopy and histopathology. Effective treatments include ketoconazole,
itraconazole, potassium iodide and co-trimoxazole. A 3 year old girl presented
with ulcerations on the right thigh for one month, and painful swelling of the
right leg and right buttock for six months. The right lower limb and vulva were
swollen, tender and hard with hyperpigmentation and inguinal lymphadenopathy. She
had severe anaemia, eosinophilia and negative serology for HIV I and II.
Histopathological examination showed a dermal chronic granulomatous infiltrate
with fungal hyphae and yeast forms suggestive of Basidiobolus ranarum. There was
marked reduction in right leg size and inguinal lymphadenopathy after several
weeks of oral itraconazole, and complete healing of ulcers after 10 weeks. The
purpose of this report is to increase awareness of this disfiguring condition
which is treatable but, if not correctly diagnosed, could result in inappropriate
interventions such as amputation and anti-coagulant therapy. FUNDING: None
declared.