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2015 ; 96
(8
): 2314-2327
Nephropedia Template TP
Frederico B
; Chao B
; Lawler C
; May JS
; Stevenson PG
J Gen Virol
2015[Aug]; 96
(8
): 2314-2327
PMID25872742
show ga
Lymphocyte proliferation, mobility and longevity make them prime targets for
virus infection. Myeloid cells that process and present environmental antigens to
lymphocytes are consequently an important line of defence. Subcapsular sinus
macrophages (SSMs) filter the afferent lymph and communicate with B-cells. How
they interact with B-cell-tropic viruses is unknown. We analysed their encounter
with murid herpesvirus-4 (MuHV-4), an experimentally accessible gammaherpesvirus
related to Kaposi's sarcoma-associated herpesvirus. MuHV-4 disseminated via lymph
nodes, and intranasally or subcutaneously inoculated virions readily infected
SSMs. However, this infection was poorly productive. SSM depletion with
clodronate-loaded liposomes or with diphtheria toxin in CD169-diphtheria toxin
receptor transgenic mice increased B-cell infection and hastened virus spread to
the spleen. Dendritic cells provided the main route to B-cells, and SSMs slowed
host colonization, apparently by absorbing virions non-productively from the
afferent lymph.
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