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10.3748/wjg.v8.i2.247

http://scihub22266oqcxt.onion/10.3748/wjg.v8.i2.247
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C4658360!4658360 !11925601
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suck abstract from ncbi


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pmid11925601
      World+J+Gastroenterol 2002 ; 8 (2 ): 247-52
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  • Study of apoptosis in human liver cancers #MMPMID11925601
  • Shan CM ; Li J
  • World J Gastroenterol 2002[Apr]; 8 (2 ): 247-52 PMID11925601 show ga
  • AIM: To investigate the action of apoptosis in occurrence of liver carcinomas in vivo and the biological effect of Solanum lyratum Thumb on BEL-7404 cell line inducing apoptosis in vivo. METHODS: The apoptosis in the liver carcinoma was detected with terminal deoxynucl neotidyl transferase mediated dUTP nick end labelling (TUNEL); the cancer cells cultured in DMED medium were treated with extract of Solanum lyratum Thumb and observed under microscope, and their DNA was assayed by gel electrophoresis. RESULTS: In vivo apoptotic cells in the cancer adjacent tissues inceased; in vivo treatment of liver cancers with extract of Solanum lyratum Thumb could induce the cells to manifest a typical apoptotic morphology. Their DNA was fractured and a characteristic ladder pattern could be found using electrophoresis. CONCLUSION: In vivo the apoptosis of carcinomas was lower; maybe the cells divided quickly and then the cancers occurred. In the cancer adjacent tissues,the apoptosis pricked up, and in vivo Solanum lyratum Thumb could induce the apoptosis of BEL-7404 cells.
  • |*Apoptosis [MESH]
  • |*Phytotherapy [MESH]
  • |*Solanum [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |In Situ Nick-End Labeling [MESH]
  • |Liver Neoplasms/*drug therapy/pathology/*physiopathology [MESH]
  • |Male [MESH]
  • |Plant Extracts/therapeutic use [MESH]


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