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10.1371/journal.pone.0188201 http://scihub22266oqcxt.onion/10.1371/journal.pone.0188201 C5687706!5687706 !29141034     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29141034 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2017 ; 12 (11 ): e0188201 Nephropedia Template TP {{tp|p=29141034 |t=2017. Structure of the human chromosome interaction network |pdf=|usr=}}{{29141034 }} gab.com Text Structure of the human chromosome interaction network JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29141034 #FOAvip New Hi-C technologies have revealed that chromosomes have a complex network of spatial contacts in the cell nucleus of higher organisms, whose organisation is only partially understood. Here, we investigate the structure of such a network in human GM12878 cells, to derive a large scale picture of nuclear architecture. We find that the intensity of intra-chromosomal interactions is power-law distributed. Inter-chromosomal interactions are two orders of magnitude weaker and exponentially distributed, yet they are not randomly arranged along the genomic sequence. Intra-chromosomal contacts broadly occur between epigenomically homologous regions, whereas inter-chromosomal contacts are especially associated with regions rich in highly expressed genes. Overall, genomic contacts in the nucleus appear to be structured as a network of networks where a set of strongly individual chromosomal units, as envisaged in the 'chromosomal territory' scenario derived from microscopy, interact with each other via on average weaker, yet far from random and functionally important interactions. Twit Text FOAVip Structure of the human chromosome interaction network ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29141034 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29141034 #FOAvip English Wikipedia <ref>{{Cite pmid|29141034 }}</ref> Structure of the human chromosome interaction network #MMPMID29141034 Sarnataro S ; Chiariello AM ; Esposito A ; Prisco A ; Nicodemi M PLoS One 2017[]; 12 (11 ): e0188201 PMID29141034 show ga New Hi-C technologies have revealed that chromosomes have a complex network of spatial contacts in the cell nucleus of higher organisms, whose organisation is only partially understood. Here, we investigate the structure of such a network in human GM12878 cells, to derive a large scale picture of nuclear architecture. We find that the intensity of intra-chromosomal interactions is power-law distributed. Inter-chromosomal interactions are two orders of magnitude weaker and exponentially distributed, yet they are not randomly arranged along the genomic sequence. Intra-chromosomal contacts broadly occur between epigenomically homologous regions, whereas inter-chromosomal contacts are especially associated with regions rich in highly expressed genes. Overall, genomic contacts in the nucleus appear to be structured as a network of networks where a set of strongly individual chromosomal units, as envisaged in the 'chromosomal territory' scenario derived from microscopy, interact with each other via on average weaker, yet far from random and functionally important interactions. |*Chromosomes, Human [MESH] |Cell Nucleus/genetics [MESH] |Genome, Human [MESH]Structure of the human chromosome interaction network (epmc).pdf DeepDyve Pubget Overpricing