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Structure biology of selective autophagy receptors
#MMPMID26698872
Kim BW
; Kwon DH
; Song HK
BMB Rep
2016[Feb]; 49
(2
): 73-80
PMID26698872
show ga
Autophagy is a process tightly regulated by various autophagy-related proteins.
It is generally classified into non-selective and selective autophagy. Whereas
non-selective autophagy is triggered when the cell is under starvation, selective
autophagy is involved in eliminating dysfunctional organelles, misfolded and/or
ubiquitylated proteins, and intracellular pathogens. These components are
recognized by autophagy receptors and delivered to phagophores. Several selective
autophagy receptors have been identified and characterized. They usually have
some common domains, such as LC3-interacting- region (LIR) motif, a specific
cargo interacting (ubiquitin-dependent or ubiquitin-independent) domain.
Recently, structural data of these autophagy receptors has been described, which
provides an insight of their function in the selective autophagic process. In
this review, we summarize the most up-to-date findings about the
structure-function of autophagy receptors that regulates selective autophagy.
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