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10.1038/ncomms8532 http://scihub22266oqcxt.onion/10.1038/ncomms8532 C4491817!4491817 !26112706     free     free     free       Nat+Commun 2015 ; 6 (?): 7532 Nephropedia Template TP {{tp|p=26112706 |t=2015. Structure and gating of the nuclear pore complex |pdf=|usr=}}{{26112706 }} gab.com Text Structure and gating of the nuclear pore complex JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26112706 #FOAvip Nuclear pore complexes (NPCs) perforate the nuclear envelope and allow the exchange of macromolecules between the nucleus and the cytoplasm. To acquire a deeper understanding of this transport mechanism, we analyse the structure of the NPC scaffold and permeability barrier, by reconstructing the Xenopus laevis oocyte NPC from native nuclear envelopes up to 20?Å resolution by cryo-electron tomography in conjunction with subtomogram averaging. In addition to resolving individual protein domains of the NPC constituents, we propose a model for the architecture of the molecular gate at its central channel. Furthermore, we compare and contrast this native NPC structure to one that exhibits reduced transport activity and unveil the spatial properties of the NPC gate. Twit Text FOAVip Structure and gating of the nuclear pore complex ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26112706 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26112706 #FOAvip English Wikipedia <ref>{{Cite pmid|26112706 }}</ref> Structure and gating of the nuclear pore complex #MMPMID26112706 Eibauer M ; Pellanda M ; Turgay Y ; Dubrovsky A ; Wild A ; Medalia O Nat Commun 2015[Jun]; 6 (?): 7532 PMID26112706 show ga Nuclear pore complexes (NPCs) perforate the nuclear envelope and allow the exchange of macromolecules between the nucleus and the cytoplasm. To acquire a deeper understanding of this transport mechanism, we analyse the structure of the NPC scaffold and permeability barrier, by reconstructing the Xenopus laevis oocyte NPC from native nuclear envelopes up to 20?Å resolution by cryo-electron tomography in conjunction with subtomogram averaging. In addition to resolving individual protein domains of the NPC constituents, we propose a model for the architecture of the molecular gate at its central channel. Furthermore, we compare and contrast this native NPC structure to one that exhibits reduced transport activity and unveil the spatial properties of the NPC gate. |Animals [MESH] |Cryoelectron Microscopy [MESH] |Humans [MESH] |Imaging, Three-Dimensional/*methods [MESH] |Ion Channel Gating/*physiology [MESH] |Models, Molecular [MESH] |Multiprotein Complexes/chemistry/ultrastructure [MESH] |Nuclear Pore/*chemistry/*ultrastructure [MESH] |Oocytes/*ultrastructure [MESH] |Protein Conformation [MESH]Structure and gating of the nuclear pore complex (epmc).pdf DeepDyve Pubget Overpricing