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10.1016/j.bbagrm.2014.04.019 http://scihub22266oqcxt.onion/10.1016/j.bbagrm.2014.04.019 C4177978!4177978 !24798077     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24798077 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biochim+Biophys+Acta 2014 ; 1839 (10 ): 939-950 Nephropedia Template TP {{tp|p=24798077 |t=2014. Structure and function of preQ(1) riboswitches |pdf=|usr=}}{{24798077 }} gab.com Text Structure and function of preQ(1) riboswitches JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=24798077 #FOAvip PreQ(1) riboswitches help regulate the biosynthesis and transport of preQ(1) (7-aminomethyl-7-deazaguanine), a precursor of the hypermodified guanine nucleotide queuosine (Q), in a number of Firmicutes, Proteobacteria, and Fusobacteria. Queuosine is almost universally found at the wobble position of the anticodon in asparaginyl, tyrosyl, histidyl and aspartyl tRNAs, where it contributes to translational fidelity. Two classes of preQ(1) riboswitches have been identified (preQ(1)-I and preQ(1)-II), and structures of examples from both classes have been determined. Both classes form H-type pseudoknots upon preQ(1) binding, each of which has distinct unusual features and modes of preQ(1) recognition. These features include an unusually long loop 2 in preQ(1)-I pseudoknots and an embedded hairpin in loop 3 in preQ(1)-II pseudoknots. PreQ(1)-I riboswitches are also notable for their unusually small aptamer domain, which has been extensively investigated by NMR, X-ray crystallography, FRET, and other biophysical methods. Here we review the discovery, structural biology, ligand specificity, cation interactions, folding, dynamics, and applications to biotechnology of preQ(1) riboswitches. This article is part of a Special Issue entitled: Riboswitches. Twit Text FOAVip Structure and function of preQ(1) riboswitches ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=24798077 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24798077 #FOAvip English Wikipedia <ref>{{Cite pmid|24798077 }}</ref> Structure and function of preQ(1) riboswitches #MMPMID24798077 Eichhorn CD ; Kang M ; Feigon J Biochim Biophys Acta 2014[Oct]; 1839 (10 ): 939-950 PMID24798077 show ga PreQ(1) riboswitches help regulate the biosynthesis and transport of preQ(1) (7-aminomethyl-7-deazaguanine), a precursor of the hypermodified guanine nucleotide queuosine (Q), in a number of Firmicutes, Proteobacteria, and Fusobacteria. Queuosine is almost universally found at the wobble position of the anticodon in asparaginyl, tyrosyl, histidyl and aspartyl tRNAs, where it contributes to translational fidelity. Two classes of preQ(1) riboswitches have been identified (preQ(1)-I and preQ(1)-II), and structures of examples from both classes have been determined. Both classes form H-type pseudoknots upon preQ(1) binding, each of which has distinct unusual features and modes of preQ(1) recognition. These features include an unusually long loop 2 in preQ(1)-I pseudoknots and an embedded hairpin in loop 3 in preQ(1)-II pseudoknots. PreQ(1)-I riboswitches are also notable for their unusually small aptamer domain, which has been extensively investigated by NMR, X-ray crystallography, FRET, and other biophysical methods. Here we review the discovery, structural biology, ligand specificity, cation interactions, folding, dynamics, and applications to biotechnology of preQ(1) riboswitches. This article is part of a Special Issue entitled: Riboswitches. äStructure and function of preQ(1) riboswitches (epmc).pdf DeepDyve Pubget Overpricing