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10.1007/s13238-011-1006-5 http://scihub22266oqcxt.onion/10.1007/s13238-011-1006-5 C4875287!4875287 !21337007     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\21337007 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Protein+Cell 2011 ; 2 (1 ): 26-40 Nephropedia Template TP {{tp|p=21337007 |t=2011. Structure and function of interleukin-17 family cytokines |pdf=|usr=}}{{21337007 }} gab.com Text Structure and function of interleukin-17 family cytokines JO: Protein Cell http://www.kidney.de/pget.php?&tw=1&pmid=21337007 #FOAvip The recently identified interleukin-17 (IL-17) cytokines family, which comprises six members in mammals (IL-17A-F), plays essential roles in the host immunity against infectious diseases and chronic inflammatory diseases. The three-dimensional structures containing IL-17A or IL-17F have become available and revealed the unique structural features of IL-17s as well as their receptors. Molecular modeling in this review shows that IL-17s may adopt a "cysteine knot" fold commonly seen in nerve growth factor (NGF) and other neurotrophins. Further modeling analysis unmasks a signature interaction feature of the IL-17F/IL-17RA complex, where a small loop of IL-17RA slots into the deep groove of the interface of IL-17F homodimer. This is quite different from the interaction between the best known four-helix cytokines and their cognate receptors. On the other hand, structure of IL-17A and its monoclonal antibody (CAT-2200) shows that, albeit that the antigenic epitope of IL-17A resides outside of the IL-17A homodimer interface, its physical proximity to the receptor binding groove may explain that antibody blockage would be achieved by interfering with the ligand-receptor interaction. This review is to summarize the advance in understanding the structure and function of IL-17 family cytokines, focusing mainly on IL-17A, IL-17F and IL-17E, in the hope of gaining better knowledge of immunotherapeutic strategies against various inflammatory diseases. Twit Text FOAVip Structure and function of interleukin-17 family cytokines ????Protein Cell http://www.kidney.de/pget.php?&tw=1&pmid=21337007 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21337007 #FOAvip English Wikipedia <ref>{{Cite pmid|21337007 }}</ref> Structure and function of interleukin-17 family cytokines #MMPMID21337007 Zhang X ; Angkasekwinai P ; Dong C ; Tang H Protein Cell 2011[Jan]; 2 (1 ): 26-40 PMID21337007 show ga The recently identified interleukin-17 (IL-17) cytokines family, which comprises six members in mammals (IL-17A-F), plays essential roles in the host immunity against infectious diseases and chronic inflammatory diseases. The three-dimensional structures containing IL-17A or IL-17F have become available and revealed the unique structural features of IL-17s as well as their receptors. Molecular modeling in this review shows that IL-17s may adopt a "cysteine knot" fold commonly seen in nerve growth factor (NGF) and other neurotrophins. Further modeling analysis unmasks a signature interaction feature of the IL-17F/IL-17RA complex, where a small loop of IL-17RA slots into the deep groove of the interface of IL-17F homodimer. This is quite different from the interaction between the best known four-helix cytokines and their cognate receptors. On the other hand, structure of IL-17A and its monoclonal antibody (CAT-2200) shows that, albeit that the antigenic epitope of IL-17A resides outside of the IL-17A homodimer interface, its physical proximity to the receptor binding groove may explain that antibody blockage would be achieved by interfering with the ligand-receptor interaction. This review is to summarize the advance in understanding the structure and function of IL-17 family cytokines, focusing mainly on IL-17A, IL-17F and IL-17E, in the hope of gaining better knowledge of immunotherapeutic strategies against various inflammatory diseases. |Amino Acid Sequence [MESH] |Animals [MESH] |Conserved Sequence [MESH] |Cysteine [MESH] |Disulfides/chemistry [MESH] |Humans [MESH] |Interleukin-17/*chemistry/*metabolism [MESH] |Molecular Sequence Data [MESH] |Protein Structure, Secondary [MESH] |Protein Structure, Tertiary [MESH]Structure and function of interleukin-17 family cytokines (epmc).pdf DeepDyve Pubget Overpricing