Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21468892
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Structure and function of WD40 domain proteins
#MMPMID21468892
Xu C
; Min J
Protein Cell
2011[Mar]; 2
(3
): 202-14
PMID21468892
show ga
The WD40 domain exhibits a ?-propeller architecture, often comprising seven
blades. The WD40 domain is one of the most abundant domains and also among the
top interacting domains in eukaryotic genomes. In this review, we will discuss
the identification, definition and architecture of the WD40 domains. WD40 domain
proteins are involved in a large variety of cellular processes, in which WD40
domains function as a protein-protein or protein-DNA interaction platform. WD40
domain mediates molecular recognition events mainly through the smaller top
surface, but also through the bottom surface and sides. So far, no WD40 domain
has been found to display enzymatic activity. We will also discuss the different
binding modes exhibited by the large versatile family of WD40 domain proteins. In
the last part of this review, we will discuss how post-translational
modifications are recognized by WD40 domain proteins.