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2017 ; 372
(1
): 43-50
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Structure and Properties of Cartilage Proteoglycans
#MMPMID29731595
Horkay F
; Basser PJ
; Hecht AM
; Geissler E
Macromol Symp
2017[Apr]; 372
(1
): 43-50
PMID29731595
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The most abundant cartilage proteoglycan is aggrecan, a bottlebrush shaped
molecule that possesses over 100 glycosaminoglycan (chondroitin sulfate and
keratan sulfate) chains. The side-chains are linear sulfated polysaccharides that
are negatively charged under physiological conditions. Aggrecan interacts with
hyaluronic acid (HA) to form large aggregates. Osmotic pressure measurements and
rheological measurements are used to study the static and dynamic behavior of
aggrecan assemblies at the macroscopic length scales. The microscopic properties
of aggrecan solutions are determined by small angle neutron scattering (SANS),
and static and dynamic light scattering (SLS and DLS). In dilute solutions
aggrecan forms microgels with a diffuse boundary, composed of loosely connected
clusters. The osmotic pressure of the aggrecan-HA system decreases with
increasing HA content. DLS yields a relaxation rate that varies as q(3), arising
from internal modes in the microgel. The relaxation rate in the solutions of the
aggrecan-HA complex is slightly greater than in the pure aggrecan solution.
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