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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Biochemistry
2017 ; 56
(3
): 445-457
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Structure and Function of AApeptides
#MMPMID28029249
Bolarinwa O
; Nimmagadda A
; Su M
; Cai J
Biochemistry
2017[Jan]; 56
(3
): 445-457
PMID28029249
show ga
The intrinsic drawbacks encountered in bioactive peptides in chemical biology and
biomedical sciences have diverted research efforts to the development of
sequence-specific peptidomimetics that are capable of mimicking the structure and
function of peptides and proteins. Modifications in the backbone and/or the side
chain of peptides have been explored to develop biomimetic molecular probes or
drug leads for biologically important targets. To expand the family of oligomeric
peptidomimetics to facilitate their further application, we recently developed a
new class of peptidomimetics, AApeptides based on a chiral peptide nucleic acid
backbone. AApeptides are resistant to proteolytic degradation and amenable to
enormous chemical diversification. Moreover, they could mimic the primary
structure of peptides and also fold into discrete secondary structure such as
helices and turn-like structures. Furthermore, they have started to show promise
in applications in material and biomedical sciences. Herein, we highlight the
structural design and some function of AApeptides and present our perspective on
their future development.
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