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10.1002/wrna.1354 http://scihub22266oqcxt.onion/10.1002/wrna.1354 C4990484!4990484 !27117863     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27117863 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27117863 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Wiley+Interdiscip+Rev+RNA 2016 ; 7 (5 ): 620-36 Nephropedia Template TP {{tp|p=27117863 |t=2016. Structural insights into ribosome translocation |pdf=|usr=}}{{27117863 }} gab.com Text Structural insights into ribosome translocation JO: Wiley Interdiscip Rev RNA http://www.kidney.de/pget.php?&tw=1&pmid=27117863 #FOAvip During protein synthesis, tRNA and mRNA are translocated from the A to P to E sites of the ribosome thus enabling the ribosome to translate one codon of mRNA after the other. Ribosome translocation along mRNA is induced by the universally conserved ribosome GTPase, elongation factor G (EF-G) in bacteria and elongation factor 2 (EF-2) in eukaryotes. Recent structural and single-molecule studies revealed that tRNA and mRNA translocation within the ribosome is accompanied by cyclic forward and reverse rotations between the large and small ribosomal subunits parallel to the plane of the intersubunit interface. In addition, during ribosome translocation, the 'head' domain of small ribosomal subunit undergoes forward- and back-swiveling motions relative to the rest of the small ribosomal subunit around the axis that is orthogonal to the axis of intersubunit rotation. tRNA/mRNA translocation is also coupled to the docking of domain IV of EF-G into the A site of the small ribosomal subunit that converts the thermally driven motions of the ribosome and tRNA into the forward translocation of tRNA/mRNA inside the ribosome. Despite recent and enormous progress made in the understanding of the molecular mechanism of ribosome translocation, the sequence of structural rearrangements of the ribosome, EF-G and tRNA during translocation is still not fully established and awaits further investigation. WIREs RNA 2016, 7:620-636. doi: 10.1002/wrna.1354 For further resources related to this article, please visit the WIREs website. Twit Text FOAVip Structural insights into ribosome translocation ????Wiley Interdiscip Rev RNA http://www.kidney.de/pget.php?&tw=1&pmid=27117863 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27117863 #FOAvip English Wikipedia <ref>{{Cite pmid|27117863 }}</ref> Structural insights into ribosome translocation #MMPMID27117863 Ling C ; Ermolenko DN Wiley Interdiscip Rev RNA 2016[Sep]; 7 (5 ): 620-36 PMID27117863 show ga During protein synthesis, tRNA and mRNA are translocated from the A to P to E sites of the ribosome thus enabling the ribosome to translate one codon of mRNA after the other. Ribosome translocation along mRNA is induced by the universally conserved ribosome GTPase, elongation factor G (EF-G) in bacteria and elongation factor 2 (EF-2) in eukaryotes. Recent structural and single-molecule studies revealed that tRNA and mRNA translocation within the ribosome is accompanied by cyclic forward and reverse rotations between the large and small ribosomal subunits parallel to the plane of the intersubunit interface. In addition, during ribosome translocation, the 'head' domain of small ribosomal subunit undergoes forward- and back-swiveling motions relative to the rest of the small ribosomal subunit around the axis that is orthogonal to the axis of intersubunit rotation. tRNA/mRNA translocation is also coupled to the docking of domain IV of EF-G into the A site of the small ribosomal subunit that converts the thermally driven motions of the ribosome and tRNA into the forward translocation of tRNA/mRNA inside the ribosome. Despite recent and enormous progress made in the understanding of the molecular mechanism of ribosome translocation, the sequence of structural rearrangements of the ribosome, EF-G and tRNA during translocation is still not fully established and awaits further investigation. WIREs RNA 2016, 7:620-636. doi: 10.1002/wrna.1354 For further resources related to this article, please visit the WIREs website. |*Protein Biosynthesis [MESH] |Eukaryota [MESH] |Peptide Elongation Factor 2/metabolism [MESH] |Peptide Elongation Factor G/metabolism [MESH] |Prokaryotic Cells [MESH] |RNA, Messenger/*metabolism [MESH] |RNA, Transfer/*metabolism [MESH]Structural insights into ribosome translocation (epmc).pdf DeepDyve Pubget Overpricing