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10.1146/annurev-immunol-032414-112258 http://scihub22266oqcxt.onion/10.1146/annurev-immunol-032414-112258 C4394028!4394028 !25622194     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25622194 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25622194 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Annu+Rev+Immunol 2015 ; 33 (ä): 393-416 Nephropedia Template TP {{tp|p=25622194 |t=2015. Structural biology of innate immunity |pdf=|usr=}}{{25622194 }} gab.com Text Structural biology of innate immunity JO: Annu Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25622194 #FOAvip Innate immune responses depend on timely recognition of pathogenic or danger signals by multiple cell surface or cytoplasmic receptors and transmission of signals for proper counteractions through adaptor and effector molecules. At the forefront of innate immunity are four major signaling pathways, including those elicited by Toll-like receptors, RIG-I-like receptors, inflammasomes, or cGAS, each with its own cellular localization, ligand specificity, and signal relay mechanism. They collectively engage a number of overlapping signaling outcomes, such as NF-?B activation, interferon response, cytokine maturation, and cell death. Several proteins often assemble into a supramolecular complex to enable signal transduction and amplification. In this article, we review the recent progress in mechanistic delineation of proteins in these pathways, their structural features, modes of ligand recognition, conformational changes, and homo- and hetero-oligomeric interactions within the supramolecular complexes. Regardless of seemingly distinct interactions and mechanisms, the recurring themes appear to consist of autoinhibited resting-state receptors, ligand-induced conformational changes, and higher-order assemblies of activated receptors, adaptors, and signaling enzymes through conserved protein-protein interactions. Twit Text FOAVip Structural biology of innate immunity ????Annu Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25622194 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25622194 #FOAvip English Wikipedia <ref>{{Cite pmid|25622194 }}</ref> Structural biology of innate immunity #MMPMID25622194 Yin Q ; Fu TM ; Li J ; Wu H Annu Rev Immunol 2015[]; 33 (ä): 393-416 PMID25622194 show ga Innate immune responses depend on timely recognition of pathogenic or danger signals by multiple cell surface or cytoplasmic receptors and transmission of signals for proper counteractions through adaptor and effector molecules. At the forefront of innate immunity are four major signaling pathways, including those elicited by Toll-like receptors, RIG-I-like receptors, inflammasomes, or cGAS, each with its own cellular localization, ligand specificity, and signal relay mechanism. They collectively engage a number of overlapping signaling outcomes, such as NF-?B activation, interferon response, cytokine maturation, and cell death. Several proteins often assemble into a supramolecular complex to enable signal transduction and amplification. In this article, we review the recent progress in mechanistic delineation of proteins in these pathways, their structural features, modes of ligand recognition, conformational changes, and homo- and hetero-oligomeric interactions within the supramolecular complexes. Regardless of seemingly distinct interactions and mechanisms, the recurring themes appear to consist of autoinhibited resting-state receptors, ligand-induced conformational changes, and higher-order assemblies of activated receptors, adaptors, and signaling enzymes through conserved protein-protein interactions. |Animals [MESH] |Humans [MESH] |Immunity, Innate/*physiology [MESH] |Inflammasomes/metabolism [MESH] |Membrane Proteins/chemistry/metabolism [MESH] |Protein Binding [MESH] |Receptors, Pattern Recognition/chemistry/metabolism [MESH] |Signal Transduction [MESH]Structural biology of innate immunity (epmc).pdf DeepDyve Pubget Overpricing