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2014 ; 6
(2
): 203-213
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Structural and mechanical functions of integrins
#MMPMID28510180
Anderson LR
; Owens TW
; Naylor MJ
Biophys Rev
2014[Jun]; 6
(2
): 203-213
PMID28510180
show ga
Integrins are ubiquitously expressed cell surface receptors that play a critical
role in regulating the interaction between a cell and its microenvironment to
control cell fate. These molecules are regulated either via their expression on
the cell surface or through a unique bidirectional signalling mechanism. However,
integrins are just the tip of the adhesome iceberg, initiating the assembly of a
large range of adaptor and signalling proteins that mediate the structural and
signalling functions of integrin. In this review, we summarise the structure of
integrins and mechanisms by which integrin activation is controlled. The
different adhesion structures formed by integrins are discussed, as well as the
mechanical and structural roles integrins play during cell migration. As the
function of integrin signalling can be quite varied based on cell type and
context, an in depth understanding of these processes will aid our understanding
of aberrant adhesion and migration, which is often associated with human
pathologies such as cancer.
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