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2015 ; 7
(7
): a021758
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Structural Components of Synaptic Plasticity and Memory Consolidation
#MMPMID26134321
Bailey CH
; Kandel ER
; Harris KM
Cold Spring Harb Perspect Biol
2015[Jul]; 7
(7
): a021758
PMID26134321
show ga
Consolidation of implicit memory in the invertebrate Aplysia and explicit memory
in the mammalian hippocampus are associated with remodeling and growth of
preexisting synapses and the formation of new synapses. Here, we compare and
contrast structural components of the synaptic plasticity that underlies these
two distinct forms of memory. In both cases, the structural changes involve
time-dependent processes. Thus, some modifications are transient and may
contribute to early formative stages of long-term memory, whereas others are more
stable, longer lasting, and likely to confer persistence to memory storage. In
addition, we explore the possibility that trans-synaptic signaling mechanisms
governing de novo synapse formation during development can be reused in the adult
for the purposes of structural synaptic plasticity and memory storage. Finally,
we discuss how these mechanisms set in motion structural rearrangements that
prepare a synapse to strengthen the same memory and, perhaps, to allow it to take
part in other memories as a basis for understanding how their anatomical
representation results in the enhanced expression and storage of memories in the
brain.