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2016 ; 11
(ä): 439-44
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Striving for optimal bronchodilation: focus on olodaterol
#MMPMID27042036
Incorvaia C
; Montagni M
; Makri E
; Riario-Sforza GG
; Ridolo E
Int J Chron Obstruct Pulmon Dis
2016[]; 11
(ä): 439-44
PMID27042036
show ga
?2-agonists were introduced in the 1940s as bronchodilators to be used in
obstructive respiratory diseases. Long-acting ?2-agonists have been a mainstay of
bronchodilating treatment for decades. Recently, agents extending their effect to
24 hours and thus allowing the once-daily administration were introduced, defined
as very-long-acting ?2-agonists. Olodaterol is a new very-long-acting ?2-agonist
that has been shown, in controlled trials, to improve lung function as well as
clinical outcomes and quality of life. Most of these trials included patients
with moderate, severe, or very severe chronic obstructive pulmonary disease
(COPD). Olodaterol has a rapid onset of action (comparable to formoterol) and
provides bronchodilation over 24 hours. In controlled trials, olodaterol was
shown to be as effective as formoterol twice daily, but significantly superior in
terms of quality of life in patients with COPD. The safety profile of olodaterol
was very good, with a rate of adverse events, including the cardiac events that
are particularly important for ?2-agonists, comparable to placebo. Also, the
efficiency of the Respimat(®) device concurs to the effectiveness of treatment.