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2016 ; 73
(22
): 4175-4202
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Striated muscle function, regeneration, and repair
#MMPMID27271751
Shadrin IY
; Khodabukus A
; Bursac N
Cell Mol Life Sci
2016[Nov]; 73
(22
): 4175-4202
PMID27271751
show ga
As the only striated muscle tissues in the body, skeletal and cardiac muscle
share numerous structural and functional characteristics, while exhibiting vastly
different size and regenerative potential. Healthy skeletal muscle harbors a
robust regenerative response that becomes inadequate after large muscle loss or
in degenerative pathologies and aging. In contrast, the mammalian heart loses its
regenerative capacity shortly after birth, leaving it susceptible to permanent
damage by acute injury or chronic disease. In this review, we compare and
contrast the physiology and regenerative potential of native skeletal and cardiac
muscles, mechanisms underlying striated muscle dysfunction, and bioengineering
strategies to treat muscle disorders. We focus on different sources for cellular
therapy, biomaterials to augment the endogenous regenerative response, and
progress in engineering and application of mature striated muscle tissues in
vitro and in vivo. Finally, we discuss the challenges and perspectives in
translating muscle bioengineering strategies to clinical practice.