Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26588184
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26588184
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Cell+Physiol
2016 ; 231
(7
): 1621-7
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Stretching Impacts Inflammation Resolution in Connective Tissue
#MMPMID26588184
Berrueta L
; Muskaj I
; Olenich S
; Butler T
; Badger GJ
; Colas RA
; Spite M
; Serhan CN
; Langevin HM
J Cell Physiol
2016[Jul]; 231
(7
): 1621-7
PMID26588184
show ga
Acute inflammation is accompanied from its outset by the release of specialized
pro-resolving mediators (SPMs), including resolvins, that orchestrate the
resolution of local inflammation. We showed earlier that, in rats with
subcutaneous inflammation of the back induced by carrageenan, stretching for
10?min twice daily reduced inflammation and improved pain, 2 weeks after
carrageenan injection. In this study, we hypothesized that stretching of
connective tissue activates local pro-resolving mechanisms within the tissue in
the acute phase of inflammation. In rats injected with carrageenan and randomized
to stretch versus no stretch for 48?h, stretching reduced inflammatory lesion
thickness and neutrophil count, and increased resolvin (RvD1) concentrations
within lesions. Furthermore, subcutaneous resolvin injection mimicked the effect
of stretching. In ex vivo experiments, stretching of connective tissue reduced
the migration of neutrophils and increased tissue RvD1 concentration. These
results demonstrate a direct mechanical impact of stretching on
inflammation-regulation mechanisms within connective tissue.