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2016 ; 11
(4
): 376-82
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Strategies to target non-T-cell HIV reservoirs
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Sacha JB
; Ndhlovu LC
Curr Opin HIV AIDS
2016[Jul]; 11
(4
): 376-82
PMID27023285
show ga
PURPOSE OF REVIEW: A central question for the HIV cure field is to determine new
ways to target clinically relevant, latently and actively replicating
HIV-infected cells beyond resting memory CD4 T cells, particularly in anatomical
areas of low drug penetrability. RECENT FINDINGS: HIV eradication strategies
being positioned for targeting HIV for extinction in the CD4 T-cell compartment
may also show promise in non-CD4 T-cells reservoirs. Furthermore, several
exciting novel therapeutic approaches specifically focused on HIV clearance from
non-CD4 T-cell populations are being developed. SUMMARY: Although reservoir
validity in these non-CD4 T cells continues to remain debated, this review will
highlight recent advances and make an argument as to their clinical relevancy as
we progress towards an HIV cure.