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2016 ; 44
(3
): 209-22
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English Wikipedia
Still searching for the engram
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Eichenbaum H
Learn Behav
2016[Sep]; 44
(3
): 209-22
PMID26944423
show ga
For nearly a century, neurobiologists have searched for the engram-the neural
representation of a memory. Early studies showed that the engram is widely
distributed both within and across brain areas and is supported by interactions
among large networks of neurons. Subsequent research has identified engrams that
support memory within dedicated functional systems for habit learning and
emotional memory, but the engram for declarative memories has been elusive.
Nevertheless, recent years have brought progress from molecular biological
approaches that identify neurons and networks that are necessary and sufficient
to support memory, and from recording approaches and population analyses that
characterize the information coded by large neural networks. These new directions
offer the promise of revealing the engrams for episodic and semantic memories.