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10.1038/srep15082 http://scihub22266oqcxt.onion/10.1038/srep15082 C4609946!4609946!26478520     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26478520.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26478520|t=2015. Stepwise evolution of pandrug-resistance in Klebsiella pneumoniae |pdf=|usr=}}{{26478520}} gab.com Text Stepwise evolution of pandrug-resistance in Klebsiella pneumoniae JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26478520 #FOAvip Carbapenem resistant Enterobacteriaceae (CRE) pose an urgent risk to global human health. CRE that are non-susceptible to all commercially available antibiotics threaten to return us to the pre-antibiotic era. Using Single Molecule Real Time (SMRT) sequencing we determined the complete genome of a pandrug-resistant Klebsiella pneumoniae isolate, representing the first complete genome sequence of CRE resistant to all commercially available antibiotics. The precise location of acquired antibiotic resistance elements, including mobile elements carrying genes for the OXA-181 carbapenemase, were defined. Intriguingly, we identified three chromosomal copies of an ISEcp1-blaOXA-181 mobile element, one of which has disrupted the mgrB regulatory gene, accounting for resistance to colistin. Our findings provide the first description of pandrug-resistant CRE at the genomic level, and reveal the critical role of mobile resistance elements in accelerating the emergence of resistance to other last resort antibiotics. Twit Text FOAVip Stepwise evolution of pandrug-resistance in Klebsiella pneumoniae ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26478520 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26478520 #FOAvip English Wikipedia <ref>{{Cite pmid|26478520}}</ref> Stepwise evolution of pandrug-resistance in Klebsiella pneumoniae #MMPMID26478520 Zowawi HM; Forde BM; Alfaresi M; Alzarouni A; Farahat Y; Chong TM; Yin WF; Chan KG; Li J; Schembri MA; Beatson SA; Paterson DL Sci Rep 2015[]; 5 (ä): ä PMID26478520show ga Carbapenem resistant Enterobacteriaceae (CRE) pose an urgent risk to global human health. CRE that are non-susceptible to all commercially available antibiotics threaten to return us to the pre-antibiotic era. Using Single Molecule Real Time (SMRT) sequencing we determined the complete genome of a pandrug-resistant Klebsiella pneumoniae isolate, representing the first complete genome sequence of CRE resistant to all commercially available antibiotics. The precise location of acquired antibiotic resistance elements, including mobile elements carrying genes for the OXA-181 carbapenemase, were defined. Intriguingly, we identified three chromosomal copies of an ISEcp1-blaOXA-181 mobile element, one of which has disrupted the mgrB regulatory gene, accounting for resistance to colistin. Our findings provide the first description of pandrug-resistant CRE at the genomic level, and reveal the critical role of mobile resistance elements in accelerating the emergence of resistance to other last resort antibiotics. äStepwise evolution of pandrug-resistance in Klebsiella pneumoniae (epmc).pdf DeepDyve Pubget Overpricing