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10.1016/j.tig.2016.04.004

http://scihub22266oqcxt.onion/10.1016/j.tig.2016.04.004
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C5065017!5065017!27230753
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suck abstract from ncbi


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pmid27230753      Trends+Genet 2016 ; 32 (7): 432-43
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  • Stepwise progression of embryonic patterning #MMPMID27230753
  • Sandler J; Stathopoulos A
  • Trends Genet 2016[Jul]; 32 (7): 432-43 PMID27230753show ga
  • It is long established that the graded distribution of Dorsal transcription factor influences spatial domains of gene expression along the dorsoventral axis of Drosophila melanogaster embryos. However, the more recent realization that Dorsal levels also change in time raises the question of whether these dynamics are instructive. Here, an overview of dorsoventral axis patterning is provided focusing on new insights identified through quantitative analysis of temporal changes in Dorsal target gene expression from one nuclear cycle to the next (?steps?). Possible roles for the step-wise progression of this patterning program are discussed including (i) tight, temporal regulation of signaling pathway activation, (ii) control of gene expression cohorts, and (iii) to ensure irreversibility of the patterning and cell fate specification process.
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