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10.1016/j.tig.2016.04.004 http://scihub22266oqcxt.onion/10.1016/j.tig.2016.04.004 C5065017!5065017 !27230753     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27230753 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Genet 2016 ; 32 (7 ): 432-443 Nephropedia Template TP {{tp|p=27230753 |t=2016. Stepwise Progression of Embryonic Patterning |pdf=|usr=}}{{27230753 }} gab.com Text Stepwise Progression of Embryonic Patterning JO: Trends Genet http://www.kidney.de/pget.php?&tw=1&pmid=27230753 #FOAvip It is long established that the graded distribution of Dorsal transcription factor influences spatial domains of gene expression along the dorsoventral (DV) axis of Drosophila melanogaster embryos. However, the more recent realization that Dorsal levels also change with time raises the question of whether these dynamics are instructive. An overview of DV axis patterning is provided, focusing on new insights identified through quantitative analysis of temporal changes in Dorsal target gene expression from one nuclear cycle to the next ('steps'). Possible roles for the stepwise progression of this patterning program are discussed including (i) tight temporal regulation of signaling pathway activation, (ii) control of gene expression cohorts, and (iii) ensuring the irreversibility of the patterning and cell fate specification process. Twit Text FOAVip Stepwise Progression of Embryonic Patterning ????Trends Genet http://www.kidney.de/pget.php?&tw=1&pmid=27230753 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27230753 #FOAvip English Wikipedia <ref>{{Cite pmid|27230753 }}</ref> Stepwise Progression of Embryonic Patterning #MMPMID27230753 Sandler JE ; Stathopoulos A Trends Genet 2016[Jul]; 32 (7 ): 432-443 PMID27230753 show ga It is long established that the graded distribution of Dorsal transcription factor influences spatial domains of gene expression along the dorsoventral (DV) axis of Drosophila melanogaster embryos. However, the more recent realization that Dorsal levels also change with time raises the question of whether these dynamics are instructive. An overview of DV axis patterning is provided, focusing on new insights identified through quantitative analysis of temporal changes in Dorsal target gene expression from one nuclear cycle to the next ('steps'). Possible roles for the stepwise progression of this patterning program are discussed including (i) tight temporal regulation of signaling pathway activation, (ii) control of gene expression cohorts, and (iii) ensuring the irreversibility of the patterning and cell fate specification process. |Animals [MESH] |Body Patterning/*genetics [MESH] |Drosophila melanogaster/*genetics/growth & development [MESH] |Embryonic Development/*genetics [MESH] |Gene Expression Regulation, Developmental/genetics [MESH] |Nuclear Proteins/genetics [MESH] |Signal Transduction/genetics [MESH]Stepwise Progression of Embryonic Patterning (epmc).pdf DeepDyve Pubget Overpricing