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10.1097/MOH.0000000000000064 http://scihub22266oqcxt.onion/10.1097/MOH.0000000000000064 C4323081!4323081 !25023469     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25023469 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25023469 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Hematol 2014 ; 21 (5 ): 430-7 Nephropedia Template TP {{tp|p=25023469 |t=2014. Stem cells, megakaryocytes, and platelets |pdf=|usr=}}{{25023469 }} gab.com Text Stem cells, megakaryocytes, and platelets JO: Curr Opin Hematol http://www.kidney.de/pget.php?&tw=1&pmid=25023469 #FOAvip PURPOSE OF REVIEW: Stem cells are an important tool for the study of ex-vivo models of megakaryopoiesis and the production of functional platelets. In this manuscript, we review the optimization of megakaryocyte and platelet differentiation and discuss the mechanistic studies and disease models that have incorporated stem cell technologies. RECENT FINDINGS: Mechanisms of cytoskeletal regulation and signal transduction have revealed insights into hierarchical dynamics of hematopoiesis, highlighting the close relationship between hematopoietic stem cells and cells of the megakaryocyte lineage. Platelet disorders have been successfully modeled and genetically corrected, and differentiation strategies have been optimized to the extent that utilizing stem cell-derived platelets for cellular therapy is feasible. SUMMARY: Studies that utilize stem cells for the efficient derivation of megakaryocytes and platelets have played a role in uncovering novel molecular mechanisms of megakaryopoiesis, modeling and correcting relevant diseases, and differentiating platelets that are functional and scalable for translation into the clinic. Efforts to derive megakaryocytes and platelets from pluripotent stem cells foster the opportunity of a revolutionary cellular therapy for the treatment of multiple platelet-associated diseases. Twit Text FOAVip Stem cells, megakaryocytes, and platelets ????Curr Opin Hematol http://www.kidney.de/pget.php?&tw=1&pmid=25023469 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25023469 #FOAvip English Wikipedia <ref>{{Cite pmid|25023469 }}</ref> Stem cells, megakaryocytes, and platelets #MMPMID25023469 Smith BW ; Murphy GJ Curr Opin Hematol 2014[Sep]; 21 (5 ): 430-7 PMID25023469 show ga PURPOSE OF REVIEW: Stem cells are an important tool for the study of ex-vivo models of megakaryopoiesis and the production of functional platelets. In this manuscript, we review the optimization of megakaryocyte and platelet differentiation and discuss the mechanistic studies and disease models that have incorporated stem cell technologies. RECENT FINDINGS: Mechanisms of cytoskeletal regulation and signal transduction have revealed insights into hierarchical dynamics of hematopoiesis, highlighting the close relationship between hematopoietic stem cells and cells of the megakaryocyte lineage. Platelet disorders have been successfully modeled and genetically corrected, and differentiation strategies have been optimized to the extent that utilizing stem cell-derived platelets for cellular therapy is feasible. SUMMARY: Studies that utilize stem cells for the efficient derivation of megakaryocytes and platelets have played a role in uncovering novel molecular mechanisms of megakaryopoiesis, modeling and correcting relevant diseases, and differentiating platelets that are functional and scalable for translation into the clinic. Efforts to derive megakaryocytes and platelets from pluripotent stem cells foster the opportunity of a revolutionary cellular therapy for the treatment of multiple platelet-associated diseases. |Animals [MESH] |Blood Platelets/cytology/*physiology [MESH] |Cell Differentiation [MESH] |Cell Lineage [MESH] |Humans [MESH] |Megakaryocytes/cytology/*physiology [MESH] |Models, Biological [MESH]Stem cells, megakaryocytes, and platelets (epmc).pdf DeepDyve Pubget Overpricing