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10.1016/j.ekir.2016.08.009

http://scihub22266oqcxt.onion/10.1016/j.ekir.2016.08.009
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suck abstract from ncbi


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      Kidney+Int+Rep 2016 ; 1 (4 ): 279-287
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  • Statin Use and Survival After Acute Kidney Injury #MMPMID29142930
  • Brar S ; Ye F ; James M ; Hemmelgarn B ; Klarenbach S ; Pannu N
  • Kidney Int Rep 2016[Nov]; 1 (4 ): 279-287 PMID29142930 show ga
  • INTRODUCTION: The incidence of acute kidney injury (AKI) in hospitalized patients is rising, and survivors are at high risk for cardiovascular events and mortality. Effective strategies that improve long-term outcomes of AKI are unknown. METHODS: A retrospective cohort study was performed between 2008 and 2011. All subjects were followed until 31 March 2013, with a minimum follow-up of 2 years. Participants were adults 18 years of age or older, who developed AKI during a hospitalization and had chronic kidney disease (CKD) following discharge (n = 19,707 mean age 69.9 years, mean postdischarge estimated glomerular filtration rate (eGFR) 43.0 ml/min/1.73 m(2)). Exposure to statins was examined prior to the index hospitalization as well as within 2 years following hospital discharge. The primary outcome was mortality; secondary outcomes included all-cause re-hospitalization and cardiovascular events. RESULTS: Within 2 years of discharge, only 38.3% of the participants were prescribed a statin. After adjustment for comorbidities, statin use prior to admission, demographics, baseline kidney function, and a number of other factors, statin use was associated with lower mortality (hazard ratio, 0.74; 95% confidence interval, 0.69, 0.79) in AKI survivors with CKD. Patients who received a statin also had a lower risk of all cause rehospitalization (adjusted hazarad ratio, 0.90; 95% confidence interval, 0.85, 0.94). Statin use was not associated with a reduction in cardiovascular events. DISCUSSION: Among AKI survivors with CKD, statin use was associated with a lower risk of mortality and rehospitalization rates. This finding suggests that there is an opportunity to improve postdischarge care in AKI survivors.
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