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2017 ; 23
(21
): 3797-3804
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Spontaneous regression of hepatocellular carcinoma: A mini-review
#MMPMID28638219
Sakamaki A
; Kamimura K
; Abe S
; Tsuchiya A
; Takamura M
; Kawai H
; Yamagiwa S
; Terai S
World J Gastroenterol
2017[Jun]; 23
(21
): 3797-3804
PMID28638219
show ga
Spontaneous tumor regression is an extremely rare phenomenon in the oncology
field. However, there are several case reports resulted in the regression of
hepatocellular carcinoma (HCC) and the accumulation of clinical information and
analyses of the mechanism can contribute to the development of a novel therapy.
For this purpose, we have carefully reviewed 23 cases of spontaneously regressed
HCC published in recent 5 years and our case. The information regarding the tumor
size, tumor marker, treatments, etc., have been summarized. The mechanism of
spontaneous regression has been discussed to date and presumed to be due to many
factors, including hypoxia and immunological reactions. In this careful review of
the 24 cases based on the clinical information, hypoxia, systemic inflammation,
and both upon spontaneous regression were seen in 3, 8, and 4 cases, respectively
among the 15 cases for which the information regarding the proposed mechanisms
are available. Recent development of immunotherapeutic approaches in oncology
shows promising results, therefore, accumulation of additional cases and analysis
of mechanisms underlying the spontaneous regression of HCC are essential and
could lead to the development of a new generation of immunotherapies including
antibodies directed against immune reactions.
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