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10.1261/rna.057919.116 http://scihub22266oqcxt.onion/10.1261/rna.057919.116 C4986885!4986885 !27530828     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27530828 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       RNA 2016 ; 22 (9 ): 1285-301 Nephropedia Template TP {{tp|p=27530828 |t=2016. Splicing-factor alterations in cancers |pdf=|usr=}}{{27530828 }} gab.com Text Splicing-factor alterations in cancers JO: RNA http://www.kidney.de/pget.php?&tw=1&pmid=27530828 #FOAvip Tumor-associated alterations in RNA splicing result either from mutations in splicing-regulatory elements or changes in components of the splicing machinery. This review summarizes our current understanding of the role of splicing-factor alterations in human cancers. We describe splicing-factor alterations detected in human tumors and the resulting changes in splicing, highlighting cell-type-specific similarities and differences. We review the mechanisms of splicing-factor regulation in normal and cancer cells. Finally, we summarize recent efforts to develop novel cancer therapies, based on targeting either the oncogenic splicing events or their upstream splicing regulators. Twit Text FOAVip Splicing-factor alterations in cancers ????RNA http://www.kidney.de/pget.php?&tw=1&pmid=27530828 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27530828 #FOAvip English Wikipedia <ref>{{Cite pmid|27530828 }}</ref> Splicing-factor alterations in cancers #MMPMID27530828 Anczuków O ; Krainer AR RNA 2016[Sep]; 22 (9 ): 1285-301 PMID27530828 show ga Tumor-associated alterations in RNA splicing result either from mutations in splicing-regulatory elements or changes in components of the splicing machinery. This review summarizes our current understanding of the role of splicing-factor alterations in human cancers. We describe splicing-factor alterations detected in human tumors and the resulting changes in splicing, highlighting cell-type-specific similarities and differences. We review the mechanisms of splicing-factor regulation in normal and cancer cells. Finally, we summarize recent efforts to develop novel cancer therapies, based on targeting either the oncogenic splicing events or their upstream splicing regulators. |*Alternative Splicing [MESH] |Animals [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Neoplasms/*genetics/metabolism [MESH] |RNA Splicing Factors/genetics/*metabolism [MESH]Splicing-factor alterations in cancers (epmc).pdf DeepDyve Pubget Overpricing