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2018 ; 46
(5
): 2169-2184
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Splicing regulation by long noncoding RNAs
#MMPMID29425321
Romero-Barrios N
; Legascue MF
; Benhamed M
; Ariel F
; Crespi M
Nucleic Acids Res
2018[Mar]; 46
(5
): 2169-2184
PMID29425321
show ga
Massive high-throughput sequencing techniques allowed the identification of
thousands of noncoding RNAs (ncRNAs) and a plethora of different mRNA processing
events occurring in higher organisms. Long ncRNAs can act directly as long
transcripts or can be processed into active small si/miRNAs. They can modulate
mRNA cleavage, translational repression or the epigenetic landscape of their
target genes. Recently, certain long ncRNAs have been shown to play a crucial
role in the regulation of alternative splicing in response to several stimuli or
during disease. In this review, we focus on recent discoveries linking gene
regulation by alternative splicing and its modulation by long and small ncRNAs.