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2018 ; 25
(9
): R467-R478
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Splicing dysregulation as a driver of breast cancer
#MMPMID29848666
Read A
; Natrajan R
Endocr Relat Cancer
2018[Sep]; 25
(9
): R467-R478
PMID29848666
show ga
Breast cancer is known to be a heterogeneous disease driven by a large repertoire
of molecular abnormalities, which contribute to its diverse clinical behaviour.
Despite the success of targeted therapy approaches for breast cancer patient
management, there is still a lack of the molecular understanding of aggressive
forms of the disease and clinical management of these patients remains difficult.
The advent of high-throughput sequencing technologies has paved the way for a
more complete understanding of the molecular make-up of the breast cancer genome.
As such, it is becoming apparent that disruption of canonical splicing within
breast cancer governs its clinical progression. In this review, we discuss the
role of dysregulation of spliceosomal component genes and associated factors in
the progression of breast cancer, their role in therapy resistance and the use of
quantitative isoform expression as potential prognostic and predictive biomarkers
with a particular focus on oestrogen receptor-positive breast cancer.
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