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2004 ; 24
(44
): 9897-902
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Spiral waves in disinhibited mammalian neocortex
#MMPMID15525774
Huang X
; Troy WC
; Yang Q
; Ma H
; Laing CR
; Schiff SJ
; Wu JY
J Neurosci
2004[Nov]; 24
(44
): 9897-902
PMID15525774
show ga
Spiral waves are a basic feature of excitable systems. Although such waves have
been observed in a variety of biological systems, they have not been observed in
the mammalian cortex during neuronal activity. Here, we report stable rotating
spiral waves in rat neocortical slices visualized by voltage-sensitive dye
imaging. Tissue from the occipital cortex (visual) was sectioned parallel to
cortical lamina to preserve horizontal connections in layers III-V
(500-mum-thick, approximately 4 x 6 mm(2)). In such tangential slices, excitation
waves propagated in two dimensions during cholinergic oscillations. Spiral waves
occurred spontaneously and alternated with plane, ring, and irregular waves. The
rotation rate of the spirals was approximately 10 turns per second, and the
rotation was linked to the oscillations in a one-cycle- one-rotation manner. A
small (<128 mum) phase singularity occurred at the center of the spirals, about
which were observed oscillations of widely distributed phases. The phase
singularity drifted slowly across the tissue ( approximately 1 mm/10 turns). We
introduced a computational model of a cortical layer that predicted and
replicated many of the features of our experimental findings. We speculate that
rotating spiral waves may provide a spatial framework to organize cortical
oscillations.
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