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2015 ; 8
(8
): 11913-21
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Sphingosylphosphorylcholine in cancer progress
#MMPMID26550104
Yue HW
; Jing QC
; Liu PP
; Liu J
; Li WJ
; Zhao J
Int J Clin Exp Med
2015[]; 8
(8
): 11913-21
PMID26550104
show ga
Sphingosylphosphorylcholine (SPC) is a naturally occurring bioactive sphingolipid
in blood plasma, metabolizing from the hydrolysis of the membrane sphingolipid.
It has been shown to exert multifunctional role in cell physiological regulation
either as an intracellular second messenger or as an extracellular agent through
G protein coupled receptors (GPCRs). Because of elevated levels of SPC in
malicious ascites of patients with cancer, the role of SPC in tumor progression
has prompted wide interest. The factor was reported to affect the proliferation
and/or migration of many cancer cells, including pancreatic cancer cells,
epithelial ovarian carcinoma cells, rat C6 glioma cells, neuroblastoma cells,
melanoma cells, and human leukemia cells. This review covers current knowledge of
the role of SPC in tumor.