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10.3109/10409238.2015.1039115 http://scihub22266oqcxt.onion/10.3109/10409238.2015.1039115 C5476942!5476942 !25923252     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25923252 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25923252 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Crit+Rev+Biochem+Mol+Biol 2015 ; 50 (4 ): 298-313 Nephropedia Template TP {{tp|p=25923252 |t=2015. Sphingosine-1-phosphate metabolism: A structural perspective |pdf=|usr=}}{{25923252 }} gab.com Text Sphingosine-1-phosphate metabolism: A structural perspective JO: Crit Rev Biochem Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25923252 #FOAvip Sphingolipids represent an important class of bioactive signaling lipids which have key roles in numerous cellular processes. Over the last few decades, the levels of bioactive sphingolipids and/or their metabolizing enzymes have been realized to be important factors involved in disease development and progression, most notably in cancer. Targeting sphingolipid-metabolizing enzymes in disease states has been the focus of many studies and has resulted in a number of pharmacological inhibitors, with some making it into the clinic as therapeutics. In order to better understand the regulation of sphingolipid-metabolizing enzymes as well as to develop much more potent and specific inhibitors, the field of sphingolipids has recently taken a turn toward structural biology. The last decade has seen the structural determination of a number of sphingolipid enzymes and effector proteins. In these terms, one of the most complete arms of the sphingolipid pathway is the sphingosine-1-phosphate (S1P) arm. The structures of proteins involved in the function and regulation of S1P are being used to investigate further the regulation of said proteins as well as in the design and development of inhibitors as potential therapeutics. Twit Text FOAVip Sphingosine-1-phosphate metabolism: A structural perspective ????Crit Rev Biochem Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25923252 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25923252 #FOAvip English Wikipedia <ref>{{Cite pmid|25923252 }}</ref> Sphingosine-1-phosphate metabolism: A structural perspective #MMPMID25923252 Pulkoski-Gross MJ ; Donaldson JC ; Obeid LM Crit Rev Biochem Mol Biol 2015[]; 50 (4 ): 298-313 PMID25923252 show ga Sphingolipids represent an important class of bioactive signaling lipids which have key roles in numerous cellular processes. Over the last few decades, the levels of bioactive sphingolipids and/or their metabolizing enzymes have been realized to be important factors involved in disease development and progression, most notably in cancer. Targeting sphingolipid-metabolizing enzymes in disease states has been the focus of many studies and has resulted in a number of pharmacological inhibitors, with some making it into the clinic as therapeutics. In order to better understand the regulation of sphingolipid-metabolizing enzymes as well as to develop much more potent and specific inhibitors, the field of sphingolipids has recently taken a turn toward structural biology. The last decade has seen the structural determination of a number of sphingolipid enzymes and effector proteins. In these terms, one of the most complete arms of the sphingolipid pathway is the sphingosine-1-phosphate (S1P) arm. The structures of proteins involved in the function and regulation of S1P are being used to investigate further the regulation of said proteins as well as in the design and development of inhibitors as potential therapeutics. |*Models, Molecular [MESH] |*Second Messenger Systems [MESH] |Aldehyde-Lyases/antagonists & inhibitors/chemistry/metabolism [MESH] |Animals [MESH] |Binding Sites [MESH] |Biological Transport/drug effects [MESH] |Enzyme Inhibitors/chemistry/pharmacology [MESH] |Humans [MESH] |Ligands [MESH] |Lysophospholipids/chemistry/*metabolism [MESH] |Membrane Transport Modulators [MESH] |Molecular Conformation [MESH] |Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors/chemistry/metabolism [MESH] |Receptors, Lysosphingolipid/agonists/antagonists & inhibitors/chemistry/metabolism [MESH] |Sphingosine-1-Phosphate Receptors [MESH]Sphingosine-1-phosphate metabolism: A structural perspective (epmc).pdf DeepDyve Pubget Overpricing