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2013 ; 117
(ä): 201-35
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Sphingosine kinase 1 in cancer
#MMPMID23290781
Heffernan-Stroud LA
; Obeid LM
Adv Cancer Res
2013[]; 117
(ä): 201-35
PMID23290781
show ga
The role of sphingolipids as bioactive signaling molecules that can regulate cell
fate decisions puts them at center stage for cancer treatment and prevention.
While ceramide and sphingosine have been established as antigrowth molecules,
sphingosine-1-phosphate (S1P) offers a progrowth message to cells. The enzymes
responsible for maintaining the balance between these "stop" or "go" signals are
the sphingosine kinases (SK), SK1 and SK2. While the relative contribution of SK2
is still being elucidated and may involve an intranuclear role, a substantial
amount of evidence suggests that regulation of sphingolipid levels by SK1 is an
important component of carcinogenesis. Here, we review the literature regarding
the role of SK1 as an oncogene that can function to enhance cancer cell viability
and promote tumor growth and metastasis; highlighting the importance of
developing specific SK1 inhibitors to supplement current cancer therapies.
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