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2015 ; 14
(ä): 55
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Sphingolipids in cardiovascular diseases and metabolic disorders
#MMPMID26076974
Borodzicz S
; Czarzasta K
; Kuch M
; Cudnoch-Jedrzejewska A
Lipids Health Dis
2015[Jun]; 14
(ä): 55
PMID26076974
show ga
Many investigations suggest the pivotal role of sphingolipids in the pathogenesis
of lifestyle diseases such as myocardial infarction, hypertension, stroke,
diabetes mellitus type 2 and obesity. Some studies suggest that sphingolipids are
important factors in cellular signal transduction. They serve as biologically
active components of cell membrane and are involved in many processes such as
proliferation, maturation and apoptosis. Recently, ceramide and
sphingosine-1-phosphate have become the target of many investigations. Ceramide
is generated in three metabolic pathways and many factors induce its production
as a cellular stress response. Ceramide has proapoptotic properties and acts as a
precursor for many other sphingolipids. Sphingosine-1-phosphate is a ceramide
derivative, acting antiapoptotically and mitogenically and it is importantly
involved in cardioprotection. Further research on the involvement of
sphingolipids in cellular pathophysiology may improve the prevention and therapy
of lifestyle diseases.