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2016 ; 40
(5
): 738-52
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Specificity and complexity in bacterial quorum-sensing systems
#MMPMID27354348
Hawver LA
; Jung SA
; Ng WL
FEMS Microbiol Rev
2016[Sep]; 40
(5
): 738-52
PMID27354348
show ga
Quorum sensing (QS) is a microbial cell-to-cell communication process that relies
on the production and detection of chemical signals called autoinducers (AIs) to
monitor cell density and species complexity in the population. QS allows bacteria
to behave as a cohesive group and coordinate collective behaviors. While most QS
receptors display high specificity to their AI ligands, others are quite
promiscuous in signal detection. How do specific QS receptors respond to their
cognate signals with high fidelity? Why do some receptors maintain low signal
recognition specificity? In addition, many QS systems are composed of multiple
intersecting signaling pathways: what are the benefits of preserving such a
complex signaling network when a simple linear 'one-to-one' regulatory pathway
seems sufficient to monitor cell density? Here, we will discuss different
molecular mechanisms employed by various QS systems that ensure productive and
specific QS responses. Moreover, the network architectures of some
well-characterized QS circuits will be reviewed to understand how the wiring of
different regulatory components achieves different biological goals.
free
free
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