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10.1895/wormbook.1.9.1 http://scihub22266oqcxt.onion/10.1895/wormbook.1.9.1 C4781390!4781390 !18050414     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\18050414 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       WormBook 2005 ; ä (ä): 1-10 Nephropedia Template TP {{tp|p=18050414 |t=2005. Specification of the germ line |pdf=|usr=}}{{18050414 }} gab.com Text Specification of the germ line JO: WormBook http://www.kidney.de/pget.php?&tw=1&pmid=18050414 #FOAvip In C. elegans, the germ line is set apart from the soma early in embryogenesis. Several important themes have emerged in specifying and guiding the development of the nascent germ line. At early stages, the germline blastomeres are maintained in a transcriptionally silent state by the transcriptional repressor PIE-1. When this silencing is lifted, it is postulated that correct patterns of germline gene expression are controlled, at least in part, by MES-mediated regulation of chromatin state. Accompanying transcriptional regulation by PIE-1 and the MES proteins, RNA metabolism in germ cells is likely to be regulated by perinuclear RNA-rich cytoplasmic granules, termed P granules. This chapter discusses the molecular nature and possible roles of these various germline regulators, and describes a recently discovered mechanism to protect somatic cells from following a germline fate. Twit Text FOAVip Specification of the germ line ????WormBook http://www.kidney.de/pget.php?&tw=1&pmid=18050414 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18050414 #FOAvip English Wikipedia <ref>{{Cite pmid|18050414 }}</ref> Specification of the germ line #MMPMID18050414 Strome S WormBook 2005[Jul]; ä (ä): 1-10 PMID18050414 show ga In C. elegans, the germ line is set apart from the soma early in embryogenesis. Several important themes have emerged in specifying and guiding the development of the nascent germ line. At early stages, the germline blastomeres are maintained in a transcriptionally silent state by the transcriptional repressor PIE-1. When this silencing is lifted, it is postulated that correct patterns of germline gene expression are controlled, at least in part, by MES-mediated regulation of chromatin state. Accompanying transcriptional regulation by PIE-1 and the MES proteins, RNA metabolism in germ cells is likely to be regulated by perinuclear RNA-rich cytoplasmic granules, termed P granules. This chapter discusses the molecular nature and possible roles of these various germline regulators, and describes a recently discovered mechanism to protect somatic cells from following a germline fate. |Animals [MESH] |Blastomeres/cytology [MESH] |Caenorhabditis elegans Proteins/physiology [MESH] |Caenorhabditis elegans/*cytology/genetics [MESH] |Cell Lineage [MESH] |Chromatin/physiology [MESH] |Cytoplasmic Granules/physiology [MESH] |Gene Expression Regulation, Developmental [MESH] |Germ Cells/*cytology [MESH] |RNA, Helminth [MESH]Specification of the germ line (epmc).pdf DeepDyve Pubget Overpricing