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10.1007/s00018-016-2134-0

http://scihub22266oqcxt.onion/10.1007/s00018-016-2134-0
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C4805691!4805691!26849156
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suck abstract from ncbi


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pmid26849156      Cell+Mol+Life+Sci 2016 ; 73 (8): 1547-67
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  • Specification and function of hemogenic endothelium during embryogenesis #MMPMID26849156
  • Gritz E; Hirschi KK
  • Cell Mol Life Sci 2016[Apr]; 73 (8): 1547-67 PMID26849156show ga
  • Hemogenic endothelium is a specialized subset of developing vascular endothelium that acquires hematopoietic potential and can give rise to multilineage hematopoietic stem and progenitor cells during a narrow developmental window in tissues such as the extraembryonic yolk sac and embryonic aorta-gonad-mesonephros. Herein, we review current knowledge about the historical and developmental origins of hemogenic endothelium, the molecular events that govern hemogenic specification of vascular endothelial cells, the generation of multilineage hematopoietic stem and progenitor cells from hemogenic endothelium, and the potential for translational applications of knowledge gained from further study of these processes.
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